The Keep it Simple theme has 4 different layout options:
-2 Columns - Right Sidebar (default.php)
-2 Columns - Left Sidebar (left_sidebar.php)
-3 Columns - Main Content, Sidebar, Sidebar (main_side_side.php)
-3 Columns - Sidebar, Main Content, Sidebar (side_main_side.php)
The theme is grid-based and is built on the 960 Grid System.
This work is distributed under the Creative Commons Attribution 2.5 License, which means that you are free to use and modify it for any purpose. All I ask is that you include a link back to styleshout.com and c5mix.com in your credits.